Zina zambiri
Growth-differentiation factor 15 (GDF15), yomwe imadziwikanso kuti MIC-1, ndi membala wobisika wa transforming growth factor (TGF) -β superfamily, monga buku la antihypertrophic regulatory factor in the heart.GDF-15 / GDF15 sichimawonetsedwa mu mtima wa munthu wamkulu koma imayendetsedwa motsatira mikhalidwe yomwe imalimbikitsa hypertrophy ndi dilated cardiomyopathy ndipo imawonetsedwa kwambiri m'chiwindi.GDF-15 / GDF15 ili ndi gawo pakuwongolera njira zotupa komanso za apoptotic mu minofu yovulala komanso panthawi ya matenda.GDF-15 / GDF15 imapangidwa ngati mamolekyu otsogola omwe amasinthidwa pamalo a dibasic cleavage kuti amasule madera a C-terminal okhala ndi mawonekedwe a 7 osungidwa ma cysteine mu mapuloteni okhwima.GDF-15 / GDF15 Kufotokozera mopambanitsa kochokera kuchipinda chokulirapo cha erythroid kumathandizira kuchulukira kwachitsulo mu ma syndromes a thalassemia poletsa mawu a hepcidin.
Awiri Malangizo | CLIA (Kujambula-Kuzindikira): 23F1-5 ~ 6C1-9 23F1-5 ~ 3A2-1 |
Chiyero | > 95%, yotsimikiziridwa ndi SDS-PAGE |
Kupanga kwa Buffer | PBS, pH7.4. |
Kusungirako | Sungani pansi pazikhalidwe zosabala pa -20 ℃ mpaka -80 ℃ mukalandira. Ndibwino kuti aliquot mapuloteniwo muchuluke kakang'ono kuti asungidwe bwino. |
Dzina lazogulitsa | Mphaka.Ayi | Clone ID |
GDF-15 | AB0038-1 | 3A2-1 |
AB0038-2 | 23F1-5 | |
AB0038-3 | 6C1-9 | |
AB0038-4 | 4D5-8 |
Chidziwitso: Bioantibody imatha makonda malinga ndi zosowa zanu.
1.Wollert KC , Kempf T , Peter T , et al.Kufunika Kwambiri kwa Kukula-Kusiyanitsa Factor-15 kwa Odwala Omwe Ali ndi Non-ST-Elevation Acute Coronary Syndrome[J].Kuzungulira, 2007, 115 (8): 962-971.
2.Kempf T, Haehling SV, Peter T, et al.Ubwino wothandiza wa kukula kusiyanitsa chinthu-15 kwa odwala omwe ali ndi vuto lalikulu la mtima.[J].Journal ya American College of Cardiology, 2007, 50 (11): 1054-1060.