Zida zoyezera mwachangu kachilombo ka Monkeypox

Zida zoyezera mwachangu kachilombo ka Monkeypox,
mayeso a monospot vs ebv serology monospot test ebv monkeypox america test for monkeypox virus mumayesa bwanji kachilombo ka powassan pali mayeso a varicella zoster virus mosaic virus nyanipox,

Zina zambiri

Bioantibody yoyamba m'kalasi komanso yodziwika bwino kwambiri idapangidwa kuti ikwaniritse zosowa zachipatala zomwe sizinakwaniritsidwe kudzera mukupanga mankhwala opangira mapuloteni amtundu wa mono ndi bi-specific, antibody drug conjugates ndi macrophage stimulating agents kwa odwala padziko lonse lapansi.

Mbiri

Kupezeka koyambilira kwaukadaulo wa monoclonal antibody (mAb) kopangidwa ndi Kohler ndi Milstein mu 1975 kunapereka mwayi wopanga ma antibodies ngati gulu lachipatala (Kohler & Milstein, 1975).Ma antibodies a Monoclonal (mAbs) ndi amodzi mwamapulatifomu omwe amagwiritsidwa ntchito kwambiri pamankhwala opatsirana kapena ochizira khansa chifukwa amasankha tizilombo toyambitsa matenda, ma cell opatsirana, maselo a khansa, komanso ma cell a chitetezo chamthupi.Mwanjira imeneyi, amayimira kuthetsa kwa mamolekyu ndi maselo omwe ali ndi zotsatira zochepa kusiyana ndi njira zina zochiritsira.Makamaka, mamAbs ochizira khansa amatha kuzindikira mapuloteni apakhungu pama cell omwe akuwatsata kenako ndikupha maselo omwe akuwunikiridwa ndi njira zingapo.
Kukhazikika kwaumunthu kumachepetsa kwambiri chitetezo chamthupi mwa anthu, kupangitsa kuti kuwongolera kosalekeza kutheke.Kupita patsogolo kotere mu matekinoloje a antibody kwadzetsa kuphulika kwa chitukuko cha ma mAbs ochizira m'zaka khumi zapitazi.Mitundu yambiri ya antibody fusions, yomwe imaphatikizapo mapuloteni a Fc-fusion, antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), ndi ma fusions a antibody-enzyme, amapangidwanso ndikugulitsidwa ngati mankhwala atsopano.

Zotsatira za mankhwala

Kwa odwala, mankhwala atsopano omwe amawaganizira amatanthauza zotsatira zochepa, zochepa zogonekedwa m'chipatala, moyo wabwino, kuwonjezeka kwa zokolola, ndipo chofunika kwambiri, moyo wautali.Koma chitukuko cha mankhwala ndi njira yayitali, yovuta.

Buku

Kohler G, Milstein C. Zikhalidwe zosalekeza za maselo osakanikirana amatulutsa ma antibodies omwe amafotokozedwatu.Chilengedwe.1975; 256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Therapeutic monoclonal antibody msika.MAB.2015; 7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-drug conjugates as novel anti-cancer chemotherapeutics.Biosci Rep. 2015;35(4):e00225.Lofalitsidwa 2015 Jul 14. Ikupezeka pa https://pubmed.ncbi.nlm.nih.gov/26182432/.Adafikira pa Julayi 2020.
Reichert, JM, ndi Valge-Archer, VE (2007).Mayendedwe akutukuka kwa monoclonal antibody therapeutics.Nat Rev Drug Discov 6, 349-356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Mitundu yopangidwa ndi antibody Fc yokhala ndi mphamvu yowonjezera.PNAS 103, 4005–4010.

Monkeypox virus ndi filovirus yomwe imayambitsa matenda opatsirana kwambiri omwe amadziwika kuti nyanipox.Zitha kupezeka m'maiko angapo a ku Africa, ngakhale zanenedwanso ku United States ndi maiko ena aku Europe.

Zizindikiro za nyanipox ndi kutentha thupi, mutu, kupweteka kwa minofu, kupweteka kwa msana, kutupa kwa lymph nodes, nseru ndi kusanza.Ziphuphu zimayambira pankhope ndi kufalikira m'thupi mpaka m'mikono ndi m'miyendo, ndipo nthawi zambiri zimazimiririka pakatha pafupifupi milungu itatu.

Ndikofunika kuzindikira kuti matendawa alibe malo osungira nyama;milandu yonse yakhala ikukhudzana ndi anthu.