Limbikitsani Njira Yopanga Mankhwala Osokoneza Bongo
Zina zambiri
Bioantibody yoyamba m'kalasi komanso yodziwika bwino kwambiri idapangidwa kuti ikwaniritse zosowa zachipatala zomwe sizinakwaniritsidwe kudzera mukupanga mankhwala opangira mapuloteni amtundu wa mono ndi bi-specific, antibody drug conjugates ndi macrophage stimulating agents kwa odwala padziko lonse lapansi.
Mbiri
Kupezeka koyambilira kwaukadaulo wa monoclonal antibody (mAb) kopangidwa ndi Kohler ndi Milstein mu 1975 kunapereka mwayi wopanga ma antibodies ngati gulu lachipatala (Kohler & Milstein, 1975).Ma antibodies a Monoclonal (mAbs) ndi amodzi mwamapulatifomu omwe amagwiritsidwa ntchito kwambiri pamankhwala opatsirana kapena ochizira khansa chifukwa amasankha tizilombo toyambitsa matenda, ma cell opatsirana, maselo a khansa, komanso ma cell a chitetezo chamthupi.Mwanjira imeneyi, amayimira kuthetsa kwa mamolekyu ndi maselo omwe ali ndi zotsatira zochepa kusiyana ndi njira zina zochiritsira.Makamaka, mamAbs ochizira khansa amatha kuzindikira mapuloteni apakhungu pama cell omwe akuwatsata kenako ndikupha maselo omwe akuwunikiridwa ndi njira zingapo.
Kukhazikika kwaumunthu kumachepetsa kwambiri chitetezo chamthupi mwa anthu, kupangitsa kuti kuwongolera kosalekeza kutheke.Kupita patsogolo kotere mu matekinoloje a antibody kwadzetsa kuphulika kwa chitukuko cha ma mAbs ochizira m'zaka khumi zapitazi.Mitundu yambiri ya antibody fusions, yomwe imaphatikizapo mapuloteni a Fc-fusion, antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), ndi ma fusions a antibody-enzyme, amapangidwanso ndikugulitsidwa ngati mankhwala atsopano.
Zotsatira za mankhwala
Kwa odwala, mankhwala atsopano omwe amawaganizira amatanthauza zotsatira zochepa, zochepa zogonekedwa m'chipatala, moyo wabwino, kuwonjezeka kwa zokolola, ndipo chofunika kwambiri, moyo wautali.Koma chitukuko cha mankhwala ndi njira yayitali, yovuta.
Buku
Kohler G, Milstein C. Zikhalidwe zosalekeza za maselo osakanikirana amatulutsa ma antibodies omwe amafotokozedwatu.Chilengedwe.1975; 256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Therapeutic monoclonal antibody msika.MAB.2015; 7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-drug conjugates as novel anti-cancer chemotherapeutics.Biosci Rep. 2015;35(4):e00225.Lofalitsidwa 2015 Jul 14. Ikupezeka pa https://pubmed.ncbi.nlm.nih.gov/26182432/.Adafikira pa Julayi 2020.
Reichert, JM, ndi Valge-Archer, VE (2007).Mayendedwe akutukuka kwa monoclonal antibody therapeutics.Nat Rev Drug Discov 6, 349-356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Mitundu yopangidwa ndi antibody Fc yokhala ndi mphamvu yowonjezera.PNAS 103, 4005–4010.
