Anti- human PIVKA -II Antibody, Mouse Monoclonal
Zambiri zamalonda
Zina zambiri
Mapuloteni Opangidwa ndi Vitamini K Kusowa kapena Antagonist-II (PIVKA-II), wotchedwanso Des-γ-carboxy-prothrombin (DCP), ndi mtundu wachilendo wa prothrombin.Nthawi zambiri, zotsalira za prothrombin 10 glutamic acid (Glu) mu γ-carboxyglutamic acid (Gla) domain pamalo 6, 7, 14, 16, 19, 20,25, 26, 29 ndi 32 ndi γ-carboxylated to Gla by vitamin. -K wodalira γ- glutamyl carboxylase m'chiwindi kenako amatulutsidwa mu plasma.Odwala omwe ali ndi hepatocellular carcinoma (HCC), γ-carboxylation ya prothrombin imasokonekera kotero kuti PIVKA-II imapangidwa m'malo mwa prothrombin.PIVKA-II imatengedwa ngati biomarker yothandiza kwambiri ya HCC.
Katundu
| Awiri Malangizo | CLIA (Kujambula-Kuzindikira): 1E5-1 ~ 1D6-10 1E5-1 ~ 1E6-7 |
| Chiyero | > 95%, yotsimikiziridwa ndi SDS-PAGE |
| Kupanga kwa Buffer | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300, pH7.4 |
| Kusungirako | Sungani pansi pazikhalidwe zosabala pa -20 ℃ mpaka -80 ℃ mukalandira. Kuti musunge nthawi yayitali, chonde aliquot ndikusunga.Pewani kuzizira kobwerezabwereza ndi kusungunuka. |
Kusanthula Kuyerekeza
Kuitanitsa Zambiri
| Dzina lazogulitsa | Mphaka.Ayi | Clone ID |
| PIVKA-Ⅱ | AB0009-1 | 1F4-5 |
| AB0009-2 | 1E5-1 | |
| AB0009-3 | 1D6-10 | |
| AB0009-4 | 1E6-7 |
Chidziwitso: Bioantibody imatha makonda malinga ndi zosowa zanu.
Zolemba
1.Matsueda K , Yamamoto H , Yoshida Y , et al.Hepatoid carcinoma ya kapamba yotulutsa mapuloteni opangidwa ndi kusowa kwa vitamini K kapena antagonist II (PIVKA-II) ndi α-fetoprotein (AFP) [J].Journal of Gastroenterology, 2006, 41 (10): 1011-1019.
2.Viggiani, Valentina, Palombi, 等.Mapuloteni opangidwa ndi kusowa kwa vitamini K kapena antagonist-II (PIVKA-II) makamaka awonjezeka mwa odwala ku Italy hepatocellular carcinoma.[J].Scandinavia Journal of Gastroenterology, 2016.
3.Simundic AM.Malingaliro othandiza pakusanthula ziwerengero ndi kufotokozera deta mu Biochemia Medica magazine[J].Biochemia Medica, 2012, 22 (1).
4.Tartaglione S , Pecorella I , Zarrillo SR , et al.Mapuloteni Opangidwa ndi Vitamin K Absence II (PIVKA-II) ngati serological biomarker mu pancreatic khansa: kafukufuku woyendetsa[J].Biochemia Medica, 2019, 29(2).
